Keynes: The second coming?

Symbolic Significance of Yeats's "The Second Coming"

The Second Coming

The definitions and characteristics of the out-of-body experience were examined. It was concluded that none of the various definitions are specific enough wRh regard to the idea of an actual physical split between the consciousness and the body. The experimental evidence was outlined, the weaknesses highlighted and alternative explanations were given. The out-of-body experience associated with ...

FGF21 and the Second Coming of PPARγ

Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospects or endorse a clinical resuscitation of PPARγ agonists?

The second coming of epigenetic drugs

L ike stem cell research, epigenetics has been promising radical new therapies, aimed at modifying the expression of target genes for a wide range of diseases. New drugs have been slow to materialize, however, largely because epigenetic mechanisms and their role in gene expression are more complex than originally thought. Nonetheless, clinically approved drugs that target epigenetic mechanisms ...

Supracricoid Partial Laryngectomy: The Second Coming

Early cancer of the larynx can be addressed by single modality treatment (surgery or radiotherapy) while advanced cancer larynx is addressed with multimodality treatment—surgery (total laryngectomy) + postoperative RT or concurrent chemotherapy + radiotherapy. But there is a subset of population with carcinoma larynx in whom single modality treatment with radiotherapy or conventional partial la...